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SELECTED PUBLICATIONS

​For complete publication list: http://www.ncbi.nlm.nih.gov/pubmed/?term=tam+wl

​

  1. Wu Z, Tam WL. (2021) A new foe in folate metabolism. Nature Metabolism. 18 Nov 2021. 10.1038/s42255-021-00474-9

  2. Loo SY, Toh LP, Xie WH, Pathak E, Tan W, Ma S, Lee MY, Shatishwaran S, JZZ Yeo, Yuan J, Ho YY, EKL Peh, Muniandy M, Torta F, Chan J, Tan T, Sim YR, Tan V, Tan B, Madhukumar M, Yong WS, Ong KW, Wong CY, Tan PH, Yap YS, Deng LW, Dent R, Foo R, Wenk MR, Lee SC, Ho YS, Lim EH#, Tam WL#. (2021) Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Science Advances. Oct 8. 7(41):eabh2443. doi: 10.1126/sciadv.abh2443. #Corresponding authors

  3. Li Z, Wang Z, Lee MC, Zenkel M, Peh E, Ozaki M, Chan A, Chen S, Nakano S, Williams SEI, Orr A, Nakano M, Kobakhidze N, Zarnowski T, Popa-Cherecheanu A, Mizoguchi T, Manabe S, Hayashi K, Kazama S, Inoue K, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Ideta R, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Mori K, Ikeda Y, Ueno M, Gaston D, Bedard K, Greer WL, Chichua G, Tabagari S, Founti P, Sim KS, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Kosior-Jarecka E, Cheong A, Li A, Lukasik U, Nongpiur ME, Husain R, Wong TY, Perera SA, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Fernández-Vega L, Martinon-Torres F, Salas A, Oguz Ç, Tamcelik N, Atalay E, Batu B, Irkec M, Aktas D, Kasım B, Astakhov YS, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Uebe S, Krumbiegel M, Welge-Luessen U-C, Mardin C, Berner D, Hoja U, Kruse FE, , Reis A, Moebus S, Carmichael TR, Hauser M, Ramsay M, Mossböck G, Nilgun Y, Tashiro K, Konstas AGP, Coca-Prados M, Foo JN, Sotozono C, Kubota T, Dubina M, Topouzis F, Ritch R, Pasutto F, Wiggs J, Schloetzer-Schrehardt U#, Ho YS#, Aung T#, Tam WL#, Khor CC#. Association of rare CYP39A1 variants with exfoliation syndrome involving the anterior chamber of the eye. (2021) Journal of the American Medical Association. 22 Feb. #Corresponding authors

  4. Sun J, Prabhu N, Tang J, Yang F, Jia L, Guo J, Xiao K, Tam WL#, Nordlund P#, Dai L#. (2021) Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules. Medicinal Research Reviews. 2021 Feb 3. doi: 10.1002/med.21788. #Corresponding authors

  5. Tan, J.L., Li, F., Yeo, J.Z., Yong, K.J., Bassal, M.A., Ng, G.H., Lee, M.Y., Leong, C.Y., Tan, H.K., Wu, C.S., Liu, B.H., Chan, T.H., Tan, Z.H., Chan, Y.S., Wang, S., Lim, Z.H., Toh, T.B., Hooi, L., Low, K.N., Ma, S., Kong, N.R., Stein, A.J., Wu, Y., Thangavelu, M.T,, Suzuki, A., Periyasamy, G., Asara, J.M., Dan, Y.Y., Bonney, G.K., Chow, E.K., Lu, G.D., Ng, H.H., Kanagasundaram, Y., Ng, S.B., Tam, W.L.#, Tenen, D.G.#, and Chai, L.# (2019) New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology. Aug 22. pii: S0016-5085(19)41242-0. doi: 10.1053/j.gastro.2019.08.022. #Corresponding authors

  6. Wang, Z., Yip, L.Y., Lee, J.H.J., Wu, Z., Chew, H.Y., Chong, P.K.W., Teo, C.C., Ang, H.Y.K, Peh, K.L.E., Yuan, J., Choo, L.S.K., Basri, N., Jiang, X., Yu, Q.,  Hillmer, A., Lim, T.K.H, Takano, A., Tan, E.H., Tan, D.S.W., Ho, Y.S., Lim, B., and Tam, W.L. (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nature Medicine. 25(5):825-837.

  7. Tan, W.L., Jain, A., Takano, A., Newell, E.W., Iyer, N.G., Lim, W.T., Tan, E.H., Zhai, W., Hillmer, A.M., Tam, W.L., and Tan, D.S.W. (2016) Novel therapeutic targets on the horizon for lung cancer. Lancet Oncology. 17:e347

  8. Zhang, W.C., Chin, T.M., Yang, H., Nga, M.N., Lunny, D.P., Lim, E.K.H., Sun, L.L., Pang, Y.H., Leow, Y.N., Malusay, S.R.Y., Lim, P.X.H., Lee, J.Z., Tan, B.J.W., Shyh-Chang, N, Lim, E.H., Lim, W.T., Tan, D.S.W., Tan, E.H., Tai, B.C., Soo, R.A., Tam, W.L.# and Lim, B.# (2016) Tumor-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. Nature Communications. 7:11702.  #Corresponding authors

  9. Pattabiraman, D.R., Bierie, B., Kober, K., Krall, J., Zill, C., Reinhardt, F., Tam, W.L. and Weinberg, R.A. (2016). Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science. 351:6277

  10. Ye, X., Tam, W.L., Shibue, T., Kaygusuz, Y., Reinhardt, F., Eaton, E. Weinberg, R.A. (2015). Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature. 525:256-60.

  11. Lu, H., Clauser, K.R., Tam, W.L., Frose, J., Reinhardt, F., Baty, C.J., Donnenberg, V.S., Carr, S.A., Weinberg, R.A. (2014). A cancer-stem-cell niche formed by juxtacrine signaling between tumor-associated macrophages and breast cancer stem cells. Nature Cell Biology. 16:1105-17.

  12. Tam, W.L. and Weinberg, R.A. (2013). The epigenetics of epithelial-mesenchymal plasticity in cancer. Nature Medicine. 19:1438-1449

  13. Tam, W.L., Lu, H., Buikhuisen, J., Soh, B.S., Lim, E., Reinhardt, F., Wu, Z.J., Krall, J.A., Bierie, B., Guo, W., Chen, X., Liu, X.S., Brown, M., Lim, B. and Weinberg, R.A. (2013). Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell. 24:347-364

  14. Han, J., Yuan, P., Yang, H., Zhang, J., Soh, B.S., Li, P., Lim, S.L., Cao, S.Y., Tay, J.L.,  Orlov, Y.L., Lufkin, T., Ng, H.H., Tam, W.L.# and Lim, B.# (2010). Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature. 463:1096-1100. #Corresponding authors

  15. Lim, C.Y.*, Tam, W.L.*,#, Zhang, J.*, Ang, H.S, Jia, H., Lipovich, L., Ng, H.H., Wei, C.L., Sung, W.K., Robson, P., Yang, H. and Lim, B.# (2008). Sall4 regulates distinct transcription circuitries in different embryo-derived stem cell lineages. Cell Stem Cell. 3:543-554. *Equal contributions; #Corresponding authors

  16. Tam, W.L., Lim, C.Y., Han, J., Zhang, J., Ang, Y.S., Ng, H.H., Yang, H.H. and Lim, B. (2008). Tcf3 regulates embryonic stem cell pluripotency and self-renewal by the repression of Oct4 and multiple lineage pathways. Stem Cells. 26:2019-2031

  17. Tay, Y.M.S.*, Tam, W.L.*, Ang, Y.S.*, Gaughwin, P.M., Wang, W.J., Liu, R., George, J., Ng, H.H., Miranda, K.C., Perera, R.J., Lufkin, T., Rigoutsos, I., Thomson, A. and Lim, B. (2008). MicroRNA-134 modulates the differentiation of mouse embryonic stem cells. Stem Cells. 26: 17-29. *Equal contributions

  18. Zhang, J.*, Tam, W.L.*, Tong, G.*, Wu, Q., Chan, H.Y., Lufkin, T., Soh, B.S., Lou, Y., Ng, H.H., Robson, P and Lim, B. (2006). Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Oct4. Nature Cell Biology. 8: 1114-1123. *Equal contributions

OTHER PUBLICATIONS

  1. Srinivas US, Tay NSC, Jaynes P, Anbuselvan A, Ramachandran GK, Wardyn JD, Hoppe MM, Hoang PM, Peng Y, Lim S, Lee MY, Peethala PC, An O, Shendre A, Tan BWQ, Jemimah S, Lakshmanan M, Hu L, Jakhar R, Sachaphibulkij K, Lim LHK, Pervaiz S, Crasta K, Yang H, Tan P, Liang C, Ho L, Khanchandani V, Kappei D, Yong WP, Tan DSP, Bordi M, Campello S, Tam WL, Frezza C, Jeyasekharan AD. (2022) PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene. Mar 2. doi: 10.1038/s41388-022-02219-8. 

  2. Nguyen PHD, Wasser M, Tan CT,  Lim CJ,  Lai HLH, Seow JJW, DasGupta R, Phua CZJ, Ma S,  Yang J,  Suthen S, Tam WL, Lim TKH, Yeong J, Leow WQ, Pang YH, Soon G, Loh TJ, Wan WK, Chan CY, Cheow PC, Toh HC, Kow A, Dan YY, Kam JH, Iyer S, Madhavan K, Chung A, Bonney GK, Goh BKP, Fu N, Yu VC, Zhai W, Albani S, Chow PKH, Chew V. (2022) Trajectory of immune evasion and cancer progression in hepatocellular carcinoma. Nature Communications. In press

  3. Suthen SD, Lim CJ, Nguyen PHD, Dutertre CA, Lai HLH, Wasser M, Chua C, Lim TKH, Leow WQ, Loh TJ, Wan WK, Pang YH, Soon G, Cheow PC, Kam JH, Iyer S, Kow A, Tam WL, Shuen TWH, Toh HC, Dan YY, Bonney GK, Chan CY, Chung A, Goh BKP, Zhai W, Ginhoux F, Chow PKH, Albani S, Chew V. (2022) Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in hepatocellular carcinoma. Hepatology. 2022 Feb 20. doi: 10.1002/hep.32419.

  4. Zhai W, Lai H, Kaya NA, Chen J, Yang H, Lu B, Lim JQ, Ma S, Chew SC, Chua KP, Alvarez JJS, Chen PJ, Chang MM, Wu L, Goh BKP, Chung AY-F, Chan CY, Cheow PC, Lee SY, Kam JH, Kow AW-C, Iyer SG, Chanwat R, Thammasiri J, Yoong BK, Ong DB-L, de Villa VH, Cruz RDD, Loh TJ, Wan WK, Zeng Z, Skanderup AJ, Pang YH, Madhavan K, Lim TK-H, Bonney G, Leow WQ, Chew V, Dan YY, Tam WL, Toh HC, Foo RS-Y, Chow PK-H (2002). Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: the PLANET study. National Science Review. In press

  5. Matsuo J, Mon NN, Douchi D, Yamamura A, Kulkarni M, Heng DL , Chen S, Nuttonmanit N , Li Y , Yang H, Lee MY, Tam WL, Osato M, Chuang LSH, Ito Y. (2022) A Runx1-enhancer element eR1 identified lineage restricted mammary luminal stem cells. Stem Cells. In press.

  6. Wang YH, Ho TLF, Hariharan A, Goh HC, Wong YL, Verkaik NS, Lee MY, Tam WL, van Gent DC, Venkitaraman AR, Sheetz MP, Lane DP. (2022) Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity. Proceedings of the National Academy of Sciences. Mar 8; 119(10):e2113233119. doi: 10.1073/pnas.2113233119.

  7. Peng B, Nguyen TM, Jayasinghe MM, Gao C, Pham TT, Vu LT, Yeo EYM, Yap G, Wang L, Goh BC, Tam WL, Luo D, Le MTN. (2022) Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy. Journal of Extracellular Vesicles. In press.

  8. Chua KP, Teng YHF, Tan AC, Takano A, Alvarez JJS, Nahar R, Rohatgi N, Lai GGY, Aung ZW, Yeong JPS, Lim KH, Naeini MM, Kassam I, Jain A, Tan WL, Gogna A, Too CW, Kanesvaran R, Ng QS, Ang MK, Rajasekaran T, Anantham D, Phua GC, Tan BS, Lee YY, Wang L, Teo ASM, Khng AJ, Lim MJ, Suteja L, Toh CK, Lim WT, Iyer NG, Tam WL, Tan EH, Zhai W, Hillmer AM, Skanderup AJ, Tan DSW. (2021) Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities. Clinical Cancer Research. Jul 14. doi: 10.1158/1078-0432.CCR-20-4607.

  9. Wu Z, Lee YF, Yeo XH, Loo SY, Tam WL. (2021) Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer. Cancers. Mar 15;13(6):1316. doi: 10.3390/cancers13061316.

  10. Chawla S, Samydurai S, Kong SL, Wu Z, Wang Z, Tam WL, Sengupta D, Kumar V. (2021) UniPath: a uniform approach for pathway and gene-set based analysis of heterogeneity in single-cell epigenome and transcriptome profiles. Nucleic Acids Research. Jan 15:gkab018. doi: 10.1093/nar/gkab018.

  11. Nguyen PHD, Ma S, Phua CZJ, Kaya NA, Lai HLH, Lim CJ, Lim JQ, Wasser M, Lai L, Tam WL, Lim TKH, Wan WK, Loh T, Leow WQ, Pang YH, Chan CY, Lee SY, Cheow PC, Toh HC, Ginhoux F, Iyer S, Kow AWC, Young Dan Y, Chung A, Goh BKP, Albani S, Chow PKH, Zhai W, Chew V. (2021) Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma. Nature Communications. 12(1):227. doi: 10.1038/s41467-020-20171-7.

  12. Jeitany M, Prabhu A, Dakle P, Pathak E, Madan V, Kanojia D, Mukundan V, Jiang YY, Landesman Y, Tam WL, Kappei D, Koeffler HP. Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas. (2020) Cellular and Molecular Life Sciences. Aug 26. doi: 10.1007/s00018-020-03620-w

  13. Tan WLW, Anene-Nzelu CG, Wong E, Lee M, Tan HS, Tang SJ, Perrin AMY, Wu KX, Zheng WH, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley M, Tam WL, Cheung C, Margulies KB, Chen L, Cappola TP, Loh M, Chambers J, Prabhakar S, Foo RS. Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype. (2020) Circulation Research. Jun 12. doi: 10.1161/CIRCRESAHA.120.317254.

  14. Adusumilli L, Facchinello N, Teh C, Busolin G, Le MT, Yang H, Beffagna G, Campanaro S, Tam WL, Argenton F, Lim B, Korzh V, Tiso N. miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. (2020) Cells. 9(3):711. doi: 10.3390/cells9030711.

  15. Chen, J., Zhang, T., Yang, H., Teo, A.S.M., Tan, C.Q., Lu, B., Alvarez, J.J.S., Lim, J.Q., Chan, C.X., Faranak, G.S., Takano, A., Nahar, R., Lee, Y.Y., Chua, K.P., Lim, C.H., Koh, T.P.T, Aung, Z.W., Lim, T.K.H, Wilm, A., Liew, A.A., Lau, D.P.X., Kwang, X.L., Toh, C.K., Lim, W.T., Lim, B., Liu, J., Tam, W.L., Tan, E.H., Creasy, C., Tan, D.S.W., Hillmer, A.M., and Zhai, W. (2020) The genomic landscape and ethnic specificity of lung Adenocarcinoma in Asia. Nature Genetics, 52(2):177-186.

  16. Kim, J.J., Lee, Y.A., Su, D., Lee, J., Park, S.J., Kim, B., Lee, J.H.J., Lee, J.S., Hong, S.C., Wang, L., Samanta, A., Kwon, H.Y., Kim, J.Y., Yu, Y.H., Ha, H.H., Wang, Z., Tam, W.L., Lim, B., Kang, N.Y., Chang, Y.T. (2019) A NIR probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society. Aug 22. doi: 10.1021/jacs.9b06068

  17. Lai, G.G.Y., Lim, T.H., Lim, J., Liew, P.J.R., Kwang, X.L., Nahar, R., Aung, Z.W., Takano, A., Lee, Y.Y., Lau, D.P.X., Tan, G.S., Tan, S.H., Tan, W.L., Ang, M.K., Toh, C.K., Tan, B.S., Devanand, A., Too, C.W., Gogna, A., Ong, B.H., Koh, T.P.T., Kanesvaran, R., Ng, Q.S., Jain, A., Rajasekaran, T., Yuan, J., Lim, T.K.H., Lim, A.S.T., Hillmer, A.M., Lim, W.T., Iyer, N.G., Tam, W.L., Zhai, W., Tan, E.H., and Tan, D.S.W. (2019) Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer. Journal of Clinical Oncology. 37(11):876-884.

  18. Sheila, M., Narayanan, G., Ma, S., Tam. W.L., Chai, J., and Stanton, L.W. (2018) Phenotypic and molecular features underlying neurodegeneration of motor neurons derived from spinal and bulbar muscular atrophy patients. Neurobiology of Disease. 124:1-13.

  19. Saei, A., Palafox, M., Benoukraf, T., Kumari, N., Jaynes, P., Iyengar, P., Muñoz-Couselo, E., Nuciforo, P., Cortés, J., Notzel, C., Kumarakulasinghe, N., Richard, J., Adam Isa, Z.B., Pang, B., Guzman, M., Siqin, Z., Yang, H., Tam, W.L., Serra, V. and Eichhorn, P. (2018) Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies. Journal of Experimental Medicine. 215(7):1913-1928.

  20. Lee, Y.-A., Kim, J.-J., Lee, J., Sahu, S., Kwon, H.-Y., Park, S.-J., Lee, J.H.J, Jang, S.-Y., Lee, J.-S., Wang, Z., Tam, W.L., Lim, B., Kang, N.-Y., Chang, Y.T. (2018) Identification of Tumour initiating cells by a small molecule fluorescent probe through vimentin as the biomarker. Angewandte Chemie International Edition. 57(11):2851-2854.

  21. Nahar, R., Zhai, W., Zhang, T., Takano, A., Khng, A.J., Lee, Y.Y., Liu, X., Lim, C.H., Koh, T.P.T., Aung, Z.W., Lim, T.K.H., Veeravalli, L., Yuan, J., Teo, A.S.M., Chan, C.X., Poh, H.M., Chua, I.M.L., Liew, A.A., Lau, D.P.X., Kwang, X.L., Toh, C.K., Lim, W.-T., Lim, B., Tam, W.L., Tan, E.H., Hillmer, A.M., Tan, D.S.W. (2018) Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing. Nature Communications. 9(1):216.

  22. Goh, J.Y., Feng, M., Wang, W., Oguz, G., Yatim, S.M.J.M., Lee, P.L., Bao, Y., Lim, T.H., Wang, P., Tam, W.L., Kodahl, A.R., Lyng, M.B., Sarma, S., Lin, S.Y., Lezhava, A., Yap, Y.S., Lim, A.S.T., Hoon, D.S.B., Ditzel, H.J., Lee, S.C., Tan, E.Y., Yu, Q. (2017) Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence. Nature Medicine. 23(11):1319-1330.

  23. Wee, Z.N., Yatim, S.M., Kohlbauer, V.K., Feng, M., Goh, J.Y., Yi, B., Lee, P.L., Zhang, S., Wang, P.P., Lim, E., Tam, W.L., Cai, Y., Ditzel, H.J., Hoon, D.S., Tan, E.Y., Yu, Q. (2015). IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel. Nature Communications. 6:8746.

  24. Shaul, Y.D., Freinkman, E., Comb, W.C., Cantor, J.R., Tam, W.L., Thiru, P., Kim, D., Pacold, M.E., Chen, W.W., Bierie, B., Possemato, R., Weinberg, R.A., Yaffe, M.B. and Sabatini, D.M. (2014). DPYD is a key component of a metabolic gene expression program required for the epithelial-mesenchymal transition. Cell. 158:1-16.

  25. Tam, W.L. and Ng, H.H. (2014). Sox2: Masterminding the root of cancer. Cancer Cell. 26:3-5.

  26. Chen, X., Iliopoulos, D., Zhang, Q., Tang, Q., Greenblatt, M.B., Hatziapostolou, M., Lim, E., Tam, W.L., Ni, M., Chen, Y., Mai, J., Shen, H., Hu, D.Z., Adoro, S., Hu, B., Song, M., Landis, M.D., Ferrar, m., Brown, M., Chang, J.C., Liu, X.S., and Glimcher, L.H. (2014). XBP1 promotes human triple negative breast cancer by controlling the hypoxia response. Nature. 508:103-107.

  27. Katz, Y., Li, F., Lambert, N., Sokol, E., Tam, W.L., Cheng, A., Airoldi, E.M., Lengner, C.J., Gupta, P.B., Yu, Z., Jaenisch, R. and Burge, C.B. (2014). Musashi Proteins are Post-transcriptional Regulators of the Epithelial-luminal Cell State. eLife. Nov 7.

  28. Guo, W., Keckesova, Z., Donaher, J.L., Shibue, T., Reinhardt, F., Itzkovitz, S., Bell, G., Tam, W.L., Tischler, V., Mani, S.A., van Oudenaarden, A., and Weinberg, R.A. (2012). Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 148:1015-1028

  29. Zhang, J., Liu, X., Datta, A., Govindarajan, K.R., Tam, W.L., George J., Liu, E.T., Murthy, K.R., Lim, B., Miller, L.D. (2009). Integrative clinico-genomic analysis identifies RAB11FIP1 as a novel breast cancer oncogene. Journal of Clinical Investigation. 119(8):2171-2183

  30. Tarasov, K.V., Tarasova, Y.S., Tam, W.L., Riordon, D.R., Elliott, S.T., Kania, G., Li, J., Yamanaka, S., Crider, D.G., Testa, G., Li, R.A., Lim, B., Stewart, C.L., Liu, Y., Van Eyk, J.E., Wersto, R.P., Wobus, A.M. and Boheler, K.R. (2008). B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. PLoS ONE. 3:e2478

  31. Tam W.L., Ang Y.S. and Lim B. (2007). The molecular basis of ageing in stem cells. Mechanisms of Ageing and Development. 128: 137-148

  32. Miranda K.C., Huynh T., Ang, Y.S., Tay Y., Tam, W.L., Thomson A.M., Lim B. and Rigoutsos I. (2006). A pattern-based method for the identification of microRNA-target sites and their corresponding RNA/RNA complexes. Cell. 126: 1203-1217

  33. Kocabas, A., Crosby, J., Ross, P.J., Otu, H.H., Beyhan, Z., Kaplan, H., Tam, W.L., Rosa, G.J.M., Halgren, R.G., Lim, B., Fernandez, E. and Cibelli, J.B. (2006). Transcriptome Analysis of the Human Oocyte. Proceedings of the National Academy of Sciences U S A. 103: 14027-14032

  34. Chew, J.L., Loh, Y.H., Zhang, W., Chen, X., Tam, W.L., Yeap, L.S., Li, P., Ang, Y.S., Lim, B., Robson, P. and Ng, H.H. (2005). Reciprocal regulation of OCT4 and SOX2 genes via Oct4/Sox2 complex in embryonic stem cells. Molecular and Cellular Biology. 25: 6031-6046

  35. Ip, Y.K., Tam, W.L., Wong, W.P. and Chew, S.F. (2005). Marine (Taeniura lymma) and freshwater (Himantura signifer) elasmobranchs synthesize urea for osmotic water retention. Physiological and Biochemical Zoology. 78:610-619

  36. Ip, Y.K., Peh, B.K., Tam, W.L., Lee, S.L. and Chew S.F. (2005). Changes in salinity and ionic compositions can act as environmental signals to induce a reduction in ammonia production in the African lungfish Protopterus dolloi. Journal of Experimental Zoology. 303A:456-463

  37. Ip, Y.K., Peh, B.K., Tam, W.L., Wong, W.P. and Chew S.F. (2005). Effects of intra-peritoneal injection with NH4Cl, urea, or NH4Cl+urea on nitrogen excretion and metabolism in the African lungfish Protopterus dolloi. Journal of Experimental Zoology. 303A:272-282  

  38. Chew, S. F., Chan, N. K., Loong, A. M., Hiong, K. C., Tam, W. L., Ip, Y.K. (2004). Nitrogen metabolism in the African lungfish (Protopterus dolloi) aestivating in a mucus cocoon on land. Journal of Experimental Biology. 207:777-786

  39. Tam, W. L., Wong, W. P., Loong, A. M., Hiong, K. C., Chew, S. F., Ballantyne, J. S., and Ip, Y. K. (2003).  The osmotic response of the Asian freshwater stingray (Himantura signifer) to increased salinity: a comparison with marine (Taeniura lymma) and Amazonian freshwater (Potamotrygon motoro) stingrays.  Journal of Experimental Biology.  206:2931-2040. [Featured in Nature (2003). 424:630]

  40. Chew, S. F., Ong, T. F., Ho, L., Tam, W. L., Loong A.M., Hiong, K.C., Wong, W. P., and Ip, Y. K. (2003).  Urea synthesis in the African lungfish Protopterus dolloi - hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure. Journal of Experimental Biology.  206: 3615-3624

  41. Chew, S. F., Wong, M. Y., Tam, W. L., and Ip, Y. K. (2003).  The snakehead Channa asiatica accumulates alanine during aerial exposure, but is incapable of sustaining locomotory activities on land through partial amino acid catabolism.  Journal of Experimental Biology.  206: 693-704

  42. Ip, Y. K., Tam, W. L., Wong, W. P., Loong A.M., Hiong, K.C., Ballantyne, J. S., and Chew, S. F. (2003).  A comparison of the effects of environmental ammonia exposure on the Asian freshwater stingray Himantura signifer and the Amazonian freshwater stingray Potamotrygon motoro. Journal of Experimental Biology.  206: 3625-3633

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